Established in 2018

The TOP-NT consortium was formed in 2018 as part of an NIH-funded UG3/UH3  phased cooperative agreement award. The UG3 phase allowed investigators to develop and internally validate a multidisciplinary battery of outcome measures or functional markers that distinguishes between types of injury induced pathology in TBI.  The TOP-NT Consortium was formed from these investigators in order to facilitate collaboration across sites and to establish data collection and sharing strategies – strategies that will enable broad access to methodologies and representative datasets. The UH3 phase supports extension and cross-validation studies for the preclinical assessments across models and sites, and implements the data collection and data sharing mechanisms developed by the TOP-NT Consortium.

Georgetown University & Uniformed Services University focus on synaptic changes after TBI and head impact. They proposed the use of Hcorr, a regional heterogeneity analysis of fMRI signal in the hippocampus to study the tuning and efficiency of neuronal subpopulations in relation to the animal’s cognitive function. 

Johns Hopkins ….



University of Florida